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Scientist

Company: Actalent
Location: Covina
Posted on: September 18, 2022

Job Description:

RELOCATING BONUS AVAILABLE FOR THOSE WILLING TO MOVE OUT OF STATEPrimary Responsibilities:--- Lead planning, design, and execution of experiments related of development and characterization of cellular immunotherapy products in coordination with R & D director.--- Analyze, and report complex data to cross functional teams in a clear and concise manner--- Mentor and train scientific staff on technical skills required to effectively perform experiments and to facilitate progression of projects (Multicolor flow cytometry, multiplex cytokine assays, Image cytometry)--- Manage multiple research projects simultaneously with the R & D team and collaborate with other departments (Process Science, Analytical Science, Quality, Manufacture) as necessary.--- Contribute to various preclinical projects within R& D and those required by clients through in-depth scientific knowledge and demonstrated experience in analytical methods used in cellular immunotherapy field--- Manage the work of multiple late preclinical stage clients effectively to drive projects to completion--- Work closely with our internal colleagues to efficiently progress early-stage CAR-T products to IND filing--- Collaborate with Process science team to scale up CAR-T products--- Provide support for drafting client reports, patents, SOPs, and peer-reviewed scientific publications--- Provide scientific and technical support to direct reports and other team members (Scientists and RA)--- Maintain precise laboratory notebooks, electronic records following high standards of data quality and integrity.--- Proactively identify and supervise solutions to challenges, risks, and changes that could lead to project delays or cost changes--- Prepare scientific/technical reports, summaries, protocols, etc, and present them to internal and external stakeholders.--- Constantly improvise research strategiesRELOCATING BONUS AVAILABLE FOR THOSE WILLING TO MOVE OUT OF STATEEducation & Professional Experience:--- Ph. D in the field of Immunology, Cell biology, Virology or Cancer biology or related life science discipline with 3+ years (Scientist) or 5+ years (Senior Scientist) or Master's degree with 7 + years relevant research experience in Immunology/Cancer biology--- Extensive experience in working with different mammalian cells lines and primary human cells (adherent tumor cells, PBMCs, primary T, NK, and macrophages)--- Experience in engineering T or other immune and tumor cell types using retro/lentiviral/nonviral platforms and downstream functional assays--- Experience with transfection, electroporation, and transduction methods--- Highly skilled in multi-parameter flow cytometric analysis of immune cells from blood products. Must be able to independently design panels, acquire, analyze, and interpret data--- Demonstrated experience in a variety of molecular, cellular, biochemical, and immunological techniques (molecular cloning, transfections, transductions, western blotting, immunoprecipitation, qPCR/ddPCR, flow cytometry, ELISA, MSD, multiplex cytokine assays)--- Experience in lentiviral packaging and characterization using qPCR, flow cytometry and ELISA--- Experience in T cell co-culture functional assays to measure T cell activation, cytokine release (ELISA or intracellular staining by FACs), proliferation (CFSE).--- Prior expertise in different cytotoxicity methods commonly used in T cell immunotherapy (Luminescence, release assays, image cytometry, and impedance assays)--- Prior experience in engineering tumor cells with shRNA, CRISPR or other genetic elements--- Direct experience working on projects in the area of adaptive T cell immunotherapy is highly desired.--- Prior research experience in antibody therapies, bispecific antibodies, and cellular therapies preferred--- Familiarity with FDA regulation of biologics and cell therapy products, IND-filing, GLP/GMP process is a plus.--- A strong academic or industry research experience in immunotherapy evidenced by high caliber publications in peer-reviewed journals is desirableRELOCATING BONUS AVAILABLE FOR THOSE WILLING TO MOVE OUT OF STATE

About Actalent:

Actalent connects passion with purpose. Our scalable talent solutions and services capabilities drive value and results and provide the expertise to help our customers achieve more. Every day, our experts around the globe are making an impact. We're supporting critical initiatives in engineering and sciences that advance how companies serve the world. Actalent promotes consultant care and engagement through experiences that enable continuous development. Our people are the difference. Actalent is an operating company of Allegis Group, the global leader in talent solutions.
The company is an equal opportunity employer and will consider all applications without regards to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

Keywords: Actalent, Covina , Scientist, Other , Covina, California

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