Senior Scientist - Targeted Protein Degradation

Company: Amgen
Location: Thousand Oaks
Posted on: December 31, 2025

Job Description:

Join Amgens Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Scientist - Targeted Protein Degradation What you will do Lets do this. Lets change the world. Amgens Induced Proximity Platform (IPP) organization is dedicated to pioneering transformative drug modalities that harness the principles of proximity biology. By developing technologies that bring proteins into close proximity, we aim to unlock access to previously undruggable targets and expand therapeutic possibilities across multiple disease areas, including Oncology, Cardiometabolic disorders, Inflammation, and Rare diseases. Within IPP, the Targeted Protein Degradation function is driving innovation in Molecular Glue Degraders small molecules that induce selective degradation of disease-relevant proteins. We are seeking a highly motivated Senior Scientist to play a central role in the discovery and development of molecular glue degraders for high-value targets Our team operates at the intersection of biology, chemistry, and technology innovation, collaborating across functions to accelerate the discovery of transformative medicines for patients in need. The successful candidate will work collaboratively with teams within IPP and partner functions to broaden our understanding of emerging IPP technologies and their and explore their practical applications. The Opportunity The Targeted Protein Degradation function within IPP is seeking a highly motivated Senior Scientist to support Molecular Glues discovery and to establish and execute phenotypic-based screening platforms. This dual focus role will be central to advancing Amgens strategy in emerging induced proximity technologies and will provide the opportunity to lead from the bench while shaping platform capabilities that enable broad discovery efforts. This position is ideal for a scientist who thrives on innovation, values collaboration, and is excited about the opportunity to integrate mechanistic biology with phenotypic screening to discover novel therapeutic opportunities. Key Responsibilities: Design, establish, and implement phenotypic-based screening platforms to enable discovery of novel induced proximity mechanisms. Develop and optimize assays that capture cellular context, functional outcomes, and disease relevance. Work with automation and high-throughput screening teams to scale phenotypic platforms for broader application across IPP. Integrate advanced imaging, omics, and data science approaches to extract actionable biological insights from phenotypic screens. Apply diverse experimental approaches, including biochemical, biophysical, and cell biology techniques, to understand degrader mechanisms of action. Partner with cross-functional teams across IPP and external collaborators to broaden the scope of induced proximity drug discovery. Share insights through internal presentations, publications, and external conferences. Provide scientific mentorship to junior scientists and contribute to fostering an environment of curiosity and innovation. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an innovator with these qualifications. Basic Qualifications: Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] Or Masters degree and 3 years of directly related experience Or Bachelors degree and 5 years of directly related experience Preferred Qualifications: PhD in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field, with postdoctoral training or equivalent industry experience. 2 years of relevant industry experience (biotechnology or pharmaceutical research). Demonstrated expertise in targeted protein degradation, molecular glue biology, or proximity-based drug discovery. Hands-on experience developing and executing cellular assays or phenotypic screening approaches. Track record of assay development for high-content or high-throughput phenotypic screening, including use of automation and advanced imaging technologies. Proficiency in cellular and molecular biology techniques, such as CRISPR-based perturbations, proteomics, or transcriptomics applied to phenotypic readouts. Experience applying systems biology and data integration approaches to interpret complex phenotypic datasets. Strong scientific creativity with a record of publications, patents, or conference presentations in relevant fields. Excellent interpersonal and communication skills; ability to work collaboratively in a matrixed research environment. What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid work arrangements, where possible Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Keywords: Amgen, Covina , Senior Scientist - Targeted Protein Degradation, Science, Research & Development , Thousand Oaks, California